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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Afatinib

Afatinib — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

SYKTYROSINE-PROTEINNSD2MUSHISTONE-LYSINEKCNH2IFNGNTMT1ADRA2BIFNB1NNMTPNMTGAMTGNMTHNMTCATECHOLABL1EPIDERMALFLT3MAPK14SRCMAPK10LCKRIPK2METBLKSLKDUALMAPK9PROTO-ONCOGENEMKNK2CSNK1EDYRK2AXLGAKMAPK11TPTEP2-CSNK1EMKNK1RECEPTOREGFREPHB6FRKHIPK4IRAK1STK10DYRK1BADKERBB4HCKMAP2K5TXKCITEPHA6ERBB2PHKG2ROS1RPS6KA6MAPKAPK2HEPATOCYTESBK1STK17AERBB3IL3PHKG1

64 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by Receptor Tyrosine Kinases14 targets overlapping
Signaling by Interleukins12 targets overlapping
Intracellular signaling by second messengers10 targets overlapping

Uncovered Pathway Targets

273 total
ADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2BRAFCDC37CDC42+263 more…

Genes present in the top pathway union that Afatinib does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 50 targets covered · evidence score 44.2

score 14,056.437
CMA1CREB1ESR1HDAC1HDAC2HDAC3HIF1AHSPB1PGRPLATADRM1CA1+38
sp600125

#2 gap-filler · 41 targets covered · evidence score 43.3

score 10,459.871
CDK5CHEK1FERFESFGFR1FGFR3FLT1FLT4HIF1AINSRJAK3KDR+29

738 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.