Aldosterone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARPGRRORCNR3C1RXRAGLUCOCORTICOIDSHBGNR5A1SERPINA6NR5A2PPARANR3C2SLCO1A1NR4A2ESRRGHNF4GNR1D1NR2C1RORB
19 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway14 targets overlapping
SUMOylation10 targets overlapping
SUMO E3 ligases SUMOylate target proteins10 targets overlapping
Uncovered Pathway Targets
90 totalESR1ESR2ESRRAESRRBHNF4ANCOR1NCOR2NR0B1NR1D2NR1H2+80 more…
Genes present in the top pathway union that Aldosterone does not directly modulate.
Top Stack Candidates
Vorinostat
score 5,952.994#1 gap-filler · 25 targets covered · evidence score 46.0
ESR1NCOR1NCOR2NR0B1HDAC1HDAC2HDAC4HDAC7MDM2MITFTP53TUBA1A+13
Nocodazole Nocodazole is
score 5,877.131#2 gap-filler · 28 targets covered · evidence score 42.9
ESRRANR0B1NR1H4NR1I2PPARGVDRBRCA1CREBBPMDM2MITFPARP1TP53+16
617 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.