alpelisib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
SYKTYROSINE-PROTEINRATTUSNSD2MUSHISTONE-LYSINEMTORABL1PHOSPHATIDYLINOSITOLPIK3CGPIK3R1PIK3CDPIK3CBGAKPIK3CAPRKACG
16 known targets mapped from PubChem bioassay data
Pathway Context
Hemostasis6 targets overlapping
Intracellular signaling by second messengers6 targets overlapping
PIP3 activates AKT signaling5 targets overlapping
Uncovered Pathway Targets
256 totalABCC4ADRA2AADRA2BADRA2CALBANXA2APPARRB1ATP1B1ATP1B2+246 more…
Genes present in the top pathway union that alpelisib does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,558.523#1 gap-filler · 48 targets covered · evidence score 44.2
F12HDAC1HDAC2IFNB1PLATTP53ADRM1CREB1ESR1ESR2HDAC3PSMA1+36
Sorafenib
score 8,337.589#2 gap-filler · 32 targets covered · evidence score 44.4
CDK5CSKFGRFYNIFNB1LCKLYNMAPK1MAPK14MAPK3MERTKPTPN6+20
725 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.