BiohacksAI/Mechanism Hypothesis/amlexanox

amlexanox — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2CYTOCHROMECYP1A2ESRRACYP3A4CYP3A7NFE2L2RORCMUSNUCLEARRARAAHRNTMT1ATAD5CASP3HDAC9GPR32GPX4PHOSPHOLIPIDGPX1GLUTATHIONESENP8ABCC4CGASGPR35RAB9ASENP6GAASENP7NPC1TNFSF10PYRUVATETBK1IKBKEGRK5

39 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations7 targets overlapping

Phase I - Functionalization of compounds7 targets overlapping

Cytochrome P450 - arranged by substrate type7 targets overlapping

Uncovered Pathway Targets

80 total

AADACAHCYALDH1A1ALDH2AOC1ARNTCBR3CES1CES2CYP11B1+70 more…

Genes present in the top pathway union that amlexanox does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 14 targets covered · evidence score 43.4

score 2,860.909

CYP19A1CYP1A1CYP1B1CYP2C8HSP90AB1MAOANNMTRXRAABCB1ABCC1ABCG2PON1+2

Ritonavir

#2 gap-filler · 9 targets covered · evidence score 53.4

score 2,631.977

CYP2B6CYP3A43CYP3A5CYP3A7-CYP3A51PUGT1A1ABCB1SLCO1B1SLCO1B3SLCO2B1

474 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.