BiohacksAI/Mechanism Hypothesis/Anisomycin

Anisomycin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1CHAINNUCLEARABCB1IFNGADRB2ATXN2ATAD5CFTRSMAD3STK33MDM2IL1BMDM4IDH1MITFYAP1PPP1R15ANR5A1PAX8NR5A2TXNRD1NLRP3NCOA3HSF1TNFRSF10BEPAS1NCOA1NR2F2MAPK14MAPK10NCOA2GLI1PRNPRIPK2SLC2A1MAPK9NOD2MAPK11MAPK8MAPK12MAPK13BCL2L11

43 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by Interleukins10 targets overlapping

Deubiquitination8 targets overlapping

Toll-like Receptor Cascades7 targets overlapping

Uncovered Pathway Targets

183 total

ADRM1ALOX15ALOX5ANXA2APPBCL2L1BIRC5CA1CASP1CCL2+173 more…

Genes present in the top pathway union that Anisomycin does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 44 targets covered · evidence score 44.2

score 12,445.115

ADRM1CA1CREB1CTSGHIF1ANFKB1NFKB2PSMA1PSMA2PSMA3PSMA4PSMA5+32

Crizotinib

#2 gap-filler · 22 targets covered · evidence score 46.7

score 6,422.518

CSF1RFYNIKBKBINPPL1IRAK1IRAK3JAK3LCKLYNMAP2K3MAP3K3MAP3K7+10

725 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.