Apigenin 5,7,4'-trihydroxy-flavone, — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2GLI3PGRNSD2TP53NR3C1ABCB1RARAESR2CYP19A1AHRPPARGVDRNTMT1ATAD5ACHECFTRNR1H4SMAD3MAPTIL1BPTGS2SMAD2CA1OPRM1POLKHIF1ACA2CREB1HDAC9PPARDCA4OPRD1BRCA1HDAC6MAOAOPRK1NFKB1APPALOX15HPGDNR0B1ABCG2RELAIP6K1SENP8CYP1B1GSK3BMAOBNPSR1AURKBSMN2ABCC1TTRAKR1B10CDK1GNAI1RGS12CLK1CSNK2A1CYP1A1GSK3AADORA1AKR1B1FLT3GABRA1GABRA2GABRA3GABRA4GABRB2GABRB3GABRG2PIM1CDK5CSNK2A2GABRA5GABRA6GABRB1GABRDGABREGABRG1GABRG3GABRPPSMB5XDHDPP4MAPK10NFKB2PKMBACE1CSNK2BPIM2SENP6STK16CDK5R1CSNK2A3SENP7MPOCCNB1CCNB2CCNB3GABRQPRKNCLK3HSD17B1IP6K2MKNK2ADORA2AAKR1C4CDK6CYBBINSRNOX4SIX1GEMTNKSTNKS2GUSBMUC1
130 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Interleukins19 targets overlapping
Signaling by Receptor Tyrosine Kinases16 targets overlapping
Neuronal System16 targets overlapping
Uncovered Pathway Targets
356 totalADRM1ALOX5ANXA2BCL2L1BIRC5CASP1CCL2CDC42CFL1CHUK+346 more…
Genes present in the top pathway union that Apigenin 5,7,4'-trihydroxy-flavone, does not directly modulate.
Top Stack Candidates
Crizotinib
score 13,130.455#1 gap-filler · 47 targets covered · evidence score 46.7
CSF1RFYNIFNGIKBKBINPPL1IRAK1IRAK3JAK3LCKLYNMAP2K3MAP3K3+35
Bortezomib
score 12,299.607#2 gap-filler · 40 targets covered · evidence score 44.2
ADRM1CTSGIFNGPSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+28
640 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.