Arsenic Trioxide — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARESR1THRBTP53
4 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation3 targets overlapping
SUMO E3 ligases SUMOylate target proteins3 targets overlapping
Deubiquitination3 targets overlapping
Uncovered Pathway Targets
148 totalAURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2+138 more…
Genes present in the top pathway union that Arsenic Trioxide does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,132.615#1 gap-filler · 48 targets covered · evidence score 44.2
HDAC1HDAC2MITFNFKB2NR1I2PARP1PGRRARARELAADRM1HIF1ANLRP3+36
Luteolin 5,7,3',4'-tetrahydroxy-flavone,
score 5,312.484#2 gap-filler · 24 targets covered · evidence score 40.6
AURKBBLMNFKB2NR1H2NR1H3PARP1PPARGRELATOP1WRNCDK1CFTR+12
654 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.