Astemizole Antihistamine drug now withdrawn from — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9ESR1CYTOCHROMETDP1THRBESRRACYP3A4SYKTYROSINE-PROTEINGLI3PGRRATTUSNSD2RORCMUSHISTONE-LYSINENUCLEARTP53ABCB1KCNH2RARACHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHOMOHTR2ADRD2ESR2DRD1CYP19A1HTR1AIFNGADRA2APPARGADRB2HTR2BTSHRADRA2CATXN2SLC6A3ACHEPMP22SLC6A4MU-TYPESLC6A2SMAD3HTR2CKAPPA-TYPEGMNNSODIUM-DEPENDENTSTK33CHRM2HRH1MDM2IL1BMDM4SMAD2ALPHA-2AABCB11IDH1MITFCASP3CHRM3ALPHA-2BHRH2HTR7HTR6PPARDALPHA-1DBRCA1ALPHA-1AALPHA-2CDRD4CASP7ALPHA-1BMUSCARINICPPP1R15AGPR151BARD1GPR32HTR5AHISTAMINEPAX8CACNA1CSIGMAR1MAP4K2TAAR1SCN5AHTR3AEPIDERMALAPAF1ITGA4KCNJ2TMEM97JAK2SIGMATACR1DELTA-TYPEBETA-3CACNA1HMELANOCORTINGHSRAVPR1AOXTRMLNRVOLTAGE-GATEDGLRA1UBE2NHRH4SUBSTANCE-KGNA15CACNA1DCACNA1FABCB1AAPLNRCACNA1SHPSEMMP14ABCB1BCYP2J2SSTR5SUBSTANCE-PKCNH1EEDGALR2HLA-A
130 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)30 targets overlapping
Amine ligand-binding receptors21 targets overlapping
G alpha (q) signalling events13 targets overlapping
Uncovered Pathway Targets
265 totalADORA2BADORA3ADRA1BADRA1DADRA2BADRB1ADRB3AGTR1AGTR2APP+255 more…
Genes present in the top pathway union that Astemizole Antihistamine drug now withdrawn from does not directly modulate.
Top Stack Candidates
Bortezomib
score 10,917.757#1 gap-filler · 35 targets covered · evidence score 44.2
CREB1ADRM1HIF1ANLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+23
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,260.364#2 gap-filler · 30 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB3CREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19+18
658 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.