Avapritinib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
TYROSINE-PROTEINABCG2ABL1KDRKITPDGFRBPLATELET-DERIVED
7 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases3 targets overlapping
Intracellular signaling by second messengers2 targets overlapping
PIP3 activates AKT signaling2 targets overlapping
Uncovered Pathway Targets
236 totalADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2AXLBRAFCDC37+226 more…
Genes present in the top pathway union that Avapritinib does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,546.668#1 gap-filler · 47 targets covered · evidence score 44.2
CMA1CREB1ESR1HDAC1HDAC2HDAC3HIF1AHSPB1PGRPLATADRM1ESR2+35
Sorafenib
score 10,406.089#2 gap-filler · 39 targets covered · evidence score 44.4
AXLBRAFCDK5CSKFGFR1FGFR2FGFR3FLT1FLT3FLT4FYNINSR+27
640 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.