Axitinib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINPGRNSD2MUSHISTONE-LYSINENUCLEARTP53RARAAHRIFNGATAD5SLC6A3CHRM2ABCB11ADORA3HDAC9HDAC6TBXA2RMAP4K2ABL1AURKBEPIDERMALFLT3MITOGEN-ACTIVATEDCSNK2A2YES1MAPK10LCKSTK16KDRRIPK2KITMETBLKCSF1RPLK4MAP3K3MACROPHAGEBCRSLKPROTO-ONCOGENERETMAP2K1AURKAAXLGAKMAP3K20MAP4K5MINK1MAPK8EPHB6IRAK1STK10FGFR1FLT4MAP4K4STK3JAK3TYK2TEKVASCULARPDGFRBPLATELET-DERIVEDABL2FGFR3FGRFLT1MAP2K2NTRK1MAP2K5TXKPKN2AAK1AURKCCDK16DDR1DDR2MAP3K19TNIKTNK2TTKROS1PAK4TBK1BMP2KCAMKK2CDKL2CSKEIF2AK2FGFR2LRRK2MAP4K3MERTKRECEPTOR-INTERACTINGSRPK1STK4TESK1TIE1TNK1ULK3ACVR2BANKK1BMPR1BCDC42BPBDLK1FECHFIBROBLASTGRK4ITKMAP3K12MAP3K4MYLK2MYLK3NUAK2RIOK1RIOK3RIPK4SRPK3ULK2CAMKK1HUNKMAP3K9MYO3AUNCHARACTERIZED
139 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases22 targets overlapping
Signaling by Interleukins15 targets overlapping
Intracellular signaling by second messengers14 targets overlapping
Uncovered Pathway Targets
281 totalADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2BRAFCDC37CDC42+271 more…
Genes present in the top pathway union that Axitinib does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,728.107#1 gap-filler · 47 targets covered · evidence score 44.2
CMA1CREB1HDAC1HDAC2HDAC3HIF1AHSPB1PLATADRM1CA1CTSGNFKB1+35
Quercetin
score 8,652.433#2 gap-filler · 38 targets covered · evidence score 43.4
ALKBRAFCREB1HIF1AHNRNPA1HSP90AA1HSPB1IGF1RMAPK14PIK3R1SPHK1SRC+26
604 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.