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BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/Azacitidine

Azacitidine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARNR1I2TDP1THRBESRRANFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCHISTONE-LYSINETP53NR3C1RARAESR2CYP19A1ATXN2ATAD5NR1H4SMAD3ALDEHYDEGMNNMDM2MDM4SMAD2IFNB1IDH1MITFCREB1YAP1TOP1P1HLA-BHTTBRCA1PPP1R15ABARD1NR5A1GAPDHTHPOADENOSINENR5A2NCOA3UHRF1NCOA1DNMT1PRNPSMARCA4HBB

50 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation14 targets overlapping
SUMO E3 ligases SUMOylate target proteins14 targets overlapping
Nuclear Receptor transcription pathway10 targets overlapping

Uncovered Pathway Targets

131 total
AURKAAURKBBIRC5BLMCREBBPCTBP1DNMT3BEIF2AK2EP300ESR1+121 more…

Genes present in the top pathway union that Azacitidine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 41 targets covered · evidence score 44.2

score 12,158.666
ESR1HDAC1HDAC2NFKB2PARP1RELAPPARDADRM1HIF1ANLRP3PSMA1PSMA2+29
Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 24 targets covered · evidence score 40.6

score 5,312.484
AURKBBLMNFKB2NR1H2NR1H3PARP1PPARGRELATOP1WRNCDK1CFTR+12

567 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.