BiohacksAI/Mechanism Hypothesis/Azathioprine

Azathioprine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9CYTOCHROMETHRBESRRANFE2L2SYKTYROSINE-PROTEINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53ABCB1RARAHOMOHTR2AAHRIFNGATAD5STK33IDH1GNRHRTXNRD1TNFRSF10BJAK2TOR1AHBB

32 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations4 targets overlapping

Drug ADME4 targets overlapping

Phase I - Functionalization of compounds4 targets overlapping

Uncovered Pathway Targets

134 total

AADACAHCYALDH1A1ALDH2AOC1ARNTCBR3CES1CES2CYP11B1+124 more…

Genes present in the top pathway union that Azathioprine does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 25 targets covered · evidence score 43.4

score 4,706.753

CYP19A1CYP1A1CYP1A2CYP1B1CYP2C8CYP3A4HSP90AB1MAOANNMTRXRAABCC1ABCG2+13

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 21 targets covered · evidence score 40.6

score 4,087.675

CBR3CYP19A1CYP1A1CYP1A2CYP1B1CYP3A4GSTO1MAOAABCG2SLCO2B1XDHAURKB+9

803 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.