Bicuculline — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
SYKTYROSINE-PROTEINGABRA1GABRA2GABRA3GABRA4GABRB2GABRB3GABRG2GABRA5GABRA6GABRB1GABRDGABREGABRG1GABRG3GABRPGAMMA-AMINOBUTYRICGABRQGABAKCNN1KCNN2
22 known targets mapped from PubChem bioassay data
Pathway Context
Neuronal System13 targets overlapping
Transmission across Chemical Synapses12 targets overlapping
Neurotransmitter receptors and postsynaptic signal transmission12 targets overlapping
Uncovered Pathway Targets
251 totalABATABCC8ABCC9ACHEADCY9ALDH2ALDH5A1BCHECACNA1BCACNA2D1+241 more…
Genes present in the top pathway union that Bicuculline does not directly modulate.
Top Stack Candidates
Sorafenib
score 10,774.624#1 gap-filler · 41 targets covered · evidence score 44.4
CAMK2BMAOAMAPK1MAPK3NTRK3RPS6KA1RPS6KA6SLC6A3SRCAXLBRAFCDK5+29
Crizotinib
score 9,438.713#2 gap-filler · 34 targets covered · evidence score 46.7
CAMKK2CASKKCNH2NTRK3PRKAA1SLC6A3SLC6A4SRCALKAXLFERFES+22
721 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.