BiohacksAI/Mechanism Hypothesis/Bortezomib

Bortezomib — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19ARNR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4NFE2L2SYKTYROSINE-PROTEINPGRRATTUSNSD2RORCHISTONE-LYSINENUCLEARTP53RARAESR2CYP19A1IFNGATXN2ATAD5SMAD3SMAD2CA1IFNB1HIF1AMITFCA2CREB1CASP3CA7TOP1P1PPARDCA12HSPB1CA4CA5AHLA-BCA5BCA9CASP7CA6NFKB1CA14SNCARELANLRP3CAR15PARP1EPAS1POLYCA3PSMB5PLGNFKB2TFE3HDAC1HDAC2HDAC3HDAC8CA13PROTHROMBINCATHEPSINPSMB1ELANEF12PROCATHEPSINPRSS1PRSS2PRSS3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMA8PSMB10PSMB11PSMB2PSMB3PSMB4PSMB6PSMB7PSMB8PSMB9PSMD1PSMD14ADRM1BROMODOMAINCAPN1CMA1CTRB1CTSACTSGLONP1PLATPROTEASOMEPSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD11PSMD12PSMD13PSMD2PSMD3PSMD4PSMD6PSMD7PSMD8SEM1

120 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by Interleukins43 targets overlapping

Signaling by NOTCH41 targets overlapping

Deubiquitination39 targets overlapping

Uncovered Pathway Targets

228 total

ALOX15ALOX5ANXA2APPBCL2L1BIRC5CASP1CCL2CDC42CFL1+218 more…

Genes present in the top pathway union that Bortezomib does not directly modulate.

Top Stack Candidates

Sorafenib

#1 gap-filler · 42 targets covered · evidence score 44.4

score 11,001.815

CSF1RFYNHCKIRAK1JAK3LCKLYNMAOAMAP2K1MAP3K7MAPK1MAPK11+30

sp600125

#2 gap-filler · 41 targets covered · evidence score 43.3

score 10,186.39

CSF1RIKBKBIL1BIRAK4JAK3LCKLYNMAPK1MAPK10MAPK8MAPK9PIM1+29

557 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.