Budesonide — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1THRBESRRACYP3A4NFE2L2GLI3PGRRORCNR3C1ABCB1RARAESR2AHRJUNCFTRIL1BKCNMB1KCNMB2KCNMA1TRHRNR3C2TLR3MAP3K3STAT1TSC22D3
30 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway9 targets overlapping
SUMOylation7 targets overlapping
SUMO E3 ligases SUMOylate target proteins7 targets overlapping
Uncovered Pathway Targets
120 totalESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+110 more…
Genes present in the top pathway union that Budesonide does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,210.059#1 gap-filler · 41 targets covered · evidence score 44.2
PPARDHDAC1HDAC2MITFNFKB2PARP1RELATP53ADRM1HDAC3PSMA1PSMA2+29
Reserpine
score 4,136.009#2 gap-filler · 15 targets covered · evidence score 41.7
TP53PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4+3
425 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.