Bumetanide — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CHAINMUSNUCLEARABCB1NTMT1CFTRCA1CA2CA7CA12CA4CA5ACA5BCA9CA6ABCC2CA14SLC22A6MAP4K2CARBONICGPR35CAR13BAP1SLC12A5SLC12A1SLC12A2
26 known targets mapped from PubChem bioassay data
Pathway Context
Reversible hydration of carbon dioxide10 targets overlapping
SLC-mediated transmembrane transport4 targets overlapping
Disorders of transmembrane transporters3 targets overlapping
Uncovered Pathway Targets
108 totalCA13CA3RUNX1SLC12A3SLC15A1SLC15A3SLC15A4SLC17A5SLC1A1SLC1A2+98 more…
Genes present in the top pathway union that Bumetanide does not directly modulate.
Top Stack Candidates
Bortezomib
score 10,829.561#1 gap-filler · 34 targets covered · evidence score 44.2
CA13CA3ADRM1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+22
Reserpine
score 4,184.679#2 gap-filler · 15 targets covered · evidence score 41.7
ABCB11PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4+3
320 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.