Buspirone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6ARNR1I2ESR1THRBESRRACYP3A7NFE2L2SYKTYROSINE-PROTEINGLI3RATTUSRORCMUSKCNH2EUCHROMATICDRD35-HYDROXYTRYPTAMINEADRA1AHOMOHTR2ADRD2DRD1HTR1AADRA2AHTR2BADRA2CADRA2BHTR2CALDEHYDEADRA1BADRA1DHTR7ALPHA-1DALPHA-1ADRD4HTR1BSIGMAR1DRD5SIGMASLC47A1
41 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)16 targets overlapping
Amine ligand-binding receptors16 targets overlapping
G alpha (q) signalling events6 targets overlapping
Uncovered Pathway Targets
211 totalADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+201 more…
Genes present in the top pathway union that Buspirone does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,200.645#1 gap-filler · 30 targets covered · evidence score 44.3
ADRB1ADRB2ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19+18
Fluspirilene
score 4,638.317#2 gap-filler · 19 targets covered · evidence score 49.7
ADORA3ADRB2CHRM3GHSRHCRTR1HRH1HTR1EHTR6MC3RMLNRNPSR1NTSR1+7
648 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.