calycosin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ESR1ESR2ATAD5BRCA1GFERPOLBNR5A1NR0B1DYRK1ASMARCA2
10 known targets mapped from PubChem bioassay data
Pathway Context
Nuclear Receptor transcription pathway4 targets overlapping
SUMOylation3 targets overlapping
SUMO E3 ligases SUMOylate target proteins3 targets overlapping
Uncovered Pathway Targets
145 totalARESRRAESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR1D1NR1D2+135 more…
Genes present in the top pathway union that calycosin does not directly modulate.
Top Stack Candidates
Bortezomib
score 13,209.617#1 gap-filler · 49 targets covered · evidence score 44.2
ARESRRANR1I2PGRPPARDRARAHDAC1HDAC2MITFNFKB2PARP1RELA+37
Quercetin
score 5,224#2 gap-filler · 27 targets covered · evidence score 43.4
ARESRRANR1I2NR3C1PGRPPARGRXRAAURKBBLMNFKB2RELATOP1+15
696 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.