BiohacksAI/Mechanism Hypothesis/cbd

cbd — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2CYP1A2CYP3A4SYKNSD2DRD1HTR2BPTGS1ADRA2CADRA2BHTR2CCHRM2PTGS2OPRM1IFNB1OPRD1HLA-BOPRK1TBXA2RGPX4CACNA1CTRPA1CYP1B1CYP1A1HRH3TMEM97CNR1ALBNR1I3CASP1FABP1GPR55TRPV1CYP2B6TRPM8CNR2CYP3A5TRPV2GPR18TRPV4

43 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)15 targets overlapping

G alpha (i) signalling events10 targets overlapping

Biological oxidations9 targets overlapping

Uncovered Pathway Targets

245 total

ADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRB1ADRB2ADRB3AGTR1+235 more…

Genes present in the top pathway union that cbd does not directly modulate.

Top Stack Candidates

Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on

#1 gap-filler · 37 targets covered · evidence score 44.3

score 10,244.42

ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3DRD2DRD3DRD4TSHRCREB1GRK2+25

Astemizole Antihistamine drug now withdrawn from

#2 gap-filler · 28 targets covered · evidence score 48.7

score 6,027.456

ADRA1AADRA2AADRB2APLNRAVPR1ACHRM1CHRM3DRD2DRD3DRD4GALR2GHSR+16

828 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.