B

BiohacksAI

Evidence-Based Biohacking

Patent Pending
BiohacksAI/Mechanism Hypothesis/celastrol

celastrol — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARCYP2C9CYTOCHROMECYP3A7SYKTYROSINE-PROTEINCHAINRATTUSNSD2MUSHISTONE-LYSINETP53HOMONTMT1ATXN2IFNB1HIF1AMITFCASP3YAP1TOP1P1HLA-BHSP90AA1ALOX12PTGER2SNCAHSF1HSP90AB1PTPN1TFE3USP17L5USP28CIB1NR4A2USP8CYBBNOX4USP10IDO1TERTUCHL1USP7PTPN2CDC37PTPN6SARM1UGT2B7CASPASE-1CYP2C11NOX1NOX5NR4A1PEROXIREDOXIN-1RGS17SPESP1-NOX5UGT1A6

56 known targets mapped from PubChem bioassay data

Pathway Context

Deubiquitination9 targets overlapping
Signaling by Receptor Tyrosine Kinases9 targets overlapping
Ub-specific processing proteases8 targets overlapping

Uncovered Pathway Targets

317 total
ADRB2ADRM1ARRB1BAP1BARD1BRCA1CCNA1CDC25ACDK1CFTR+307 more…

Genes present in the top pathway union that celastrol does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 51 targets covered · evidence score 44.2

score 14,462.629
ADRM1ESR1NLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+39
Sorafenib

#2 gap-filler · 49 targets covered · evidence score 44.4

score 12,705.61
CDK1MAP3K7RIPK2TGFBR2AXLBRAFCDK5CSKFGFR1FGFR2FGFR3FLT1+37

751 more candidates · full stack optimisation locked

Enter your API token to unlock the complete analysis.

BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.