BiohacksAI/Mechanism Hypothesis/Celecoxib

Celecoxib — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETHRBESRRACYP3A4CYP3A7NFE2L2CHAINGLI3PGRRATTUSRORCMUSNR3C1KCNH2RARAHOMOHTR2ADRD2CYP19A1IFNGADRB2TSHRPTGS1ADRA2BSLC6A3SLC6A4SMAD3SODIUM-DEPENDENTPTGS2SMAD2OPRM1CA2ADORA3CASP3HDAC9ALPHA-2BCA7CA12CA4CA5AHDAC6CA5BCA9CASP7CA6ADRB3PTGER2ALOX15CA14PLA2G7CAR15CARBONICALOX5MELANOCORTINPROSTAGLANDINCA3HDAC10HDAC11HDAC4HDAC5HDAC7MAPK14HDAC1HDAC2HDAC3HDAC8CA13VOLTAGE-GATEDPTGESSTAT3COX2

77 known targets mapped from PubChem bioassay data

Pathway Context

Signaling by NOTCH12 targets overlapping

Signaling by NOTCH111 targets overlapping

NOTCH1 Intracellular Domain Regulates Transcription11 targets overlapping

Uncovered Pathway Targets

69 total

ADAM10ADAM17ADRM1AGO2APH1AAPH1BARRB1ATP2A1ATP2A2ATP2A3+59 more…

Genes present in the top pathway union that Celecoxib does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 36 targets covered · evidence score 44.2

score 11,142.042

ADRM1CREB1ELANEHIF1APSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+24

Reserpine

#2 gap-filler · 15 targets covered · evidence score 41.7

score 4,136.009

PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4PSMB5+3

280 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.