BiohacksAI/Mechanism Hypothesis/Ciclopirox

Ciclopirox — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARESR1TDP1CYP1A2THRBSYKTYROSINE-PROTEINCHAINGLI3PGRRATTUSNSD2RORCHISTONE-LYSINENUCLEARTP53NR3C1DRD3ESR2ATXN2ATAD5PMP22SMAD3MDM2MDM4SMAD2IDH1MITFCREB1HSPB1BRCA1BAZ2BHSP90AA1PPP1R15ABARD1ALOX12GPR32PAX8

38 known targets mapped from PubChem bioassay data

Pathway Context

Deubiquitination9 targets overlapping

SUMOylation8 targets overlapping

SUMO E3 ligases SUMOylate target proteins8 targets overlapping

Uncovered Pathway Targets

255 total

ADRB2ADRM1ARRB1BAP1CCNA1CDC25ACDK1CFTREP300HIF1A+245 more…

Genes present in the top pathway union that Ciclopirox does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 44 targets covered · evidence score 44.2

score 12,755.197

ADRM1HIF1ANLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+32

Quercetin

#2 gap-filler · 38 targets covered · evidence score 43.4

score 8,816.136

CDK1HIF1AOTUD3POLBPSMB5UCHL1USP10USP17L5USP28USP30USP7USP8+26

658 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.