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BiohacksAI

Evidence-Based Biohacking

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BiohacksAI/Mechanism Hypothesis/Cinnarizine

Cinnarizine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARCYP2C9ESR1CYP3A7NFE2L2GLI3TP53ABCB1KCNH2CHRM1DRD35-HYDROXYTRYPTAMINEADRA1ADRD2ESR2DRD1HTR1AADRA2AJUNSLC6A3SLC6A4MU-TYPESLC6A2SODIUM-DEPENDENTCHRM2HRH1ALPHA-2AALPHA-2BALPHA-1DALPHA-1AALPHA-2CALPHA-1BMUSCARINICSCN2AHISTAMINESCN3AMAP4K2SCN1ANPSR1CDK1SIGMAABHD4CFL1

44 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)10 targets overlapping
Amine ligand-binding receptors9 targets overlapping
Deubiquitination4 targets overlapping

Uncovered Pathway Targets

306 total
ADORA2BADORA3ADRA1BADRA1DADRA2BADRA2CADRB1ADRB2ADRB3AGTR1+296 more…

Genes present in the top pathway union that Cinnarizine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 41 targets covered · evidence score 44.2

score 12,057.577
ADRM1HIF1ANLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+29
Quercetin

#2 gap-filler · 40 targets covered · evidence score 43.4

score 8,842.705
ADORA3APPAVPR2CCR4CXCR1DRD4GPR35HIF1AOTUD3POLBPSMB5SMAD2+28

800 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.