Codeine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARNFE2L2GLI3RATTUSMUSABCB1RARAMU-TYPEKAPPA-TYPEOPRM1ADRB1OPRD1OPRK1PDE4DCGMP-INHIBITEDMAS-RELATEDMRGPRX2
17 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)4 targets overlapping
G alpha (i) signalling events4 targets overlapping
Peptide ligand-binding receptors3 targets overlapping
Uncovered Pathway Targets
263 totalADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2ADRB3+253 more…
Genes present in the top pathway union that Codeine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 10,111.41#1 gap-filler · 36 targets covered · evidence score 44.3
ADRA1AADRA1BADRA1DADRB2ADRB3DRD2DRD3DRD4TSHRCREB1GRK2TAS2R1+24
Astemizole Antihistamine drug now withdrawn from
score 7,519.448#2 gap-filler · 38 targets covered · evidence score 48.7
ADRA1AADRA2AADRA2CADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD1DRD2DRD3+26
939 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.