BiohacksAI/Mechanism Hypothesis/Colchicine

Colchicine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRANFE2L2SYKTYROSINE-PROTEINGLI3RATTUSNSD2RORCMUSHISTONE-LYSINENUCLEARTP53ABCB1RARAIFNGVDRHTR2BJUNATAD5PMP22NR1H4SMAD3GMNNSTK33MDM2MDM4SMAD2YAP1TOP1P1BRCA1BARD1PAX8NR0B1PIM1CXCL8GLRA1SLC22A3KLF5TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TRPM7CREBBPTUBULINGLRA2TUBB8BTUBA8TUBAL3

69 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle25 targets overlapping

Neuronal System20 targets overlapping

Transmission across Chemical Synapses20 targets overlapping

Uncovered Pathway Targets

287 total

ABL1ADRM1AKT3ATMAURKAAURKBBIRC5BLMCCNA1CCNB1+277 more…

Genes present in the top pathway union that Colchicine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 40 targets covered · evidence score 44.2

score 12,116.66

ADRM1HDAC1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+28

sp600125

#2 gap-filler · 33 targets covered · evidence score 43.3

score 8,613.926

AURKAAURKBCCNA1CDC7CDK1CDK2CHEK1CHEK2CSNK1A1CSNK1DCSNK1ECSNK2A1+21

629 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.