Crizotinib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6CYP2C9NR1I2CYTOCHROMECYP3A7SYKTYROSINE-PROTEINNSD2HISTONE-LYSINEKCNH25-HYDROXYTRYPTAMINEADRA1AIFNGHTR2BPTGS1ADRA2CNTMT1SLC6A3SLC6A4SLC6A2SODIUM-DEPENDENTIFNB1ADORA3NNMTPNMTHRH2GAMTGNMTHNMTCATECHOLHLA-BPDE4DCACNA1CMAP4K2ABL1NPY1RAURKBEPIDERMALFLT3PHOSPHATIDYLINOSITOLMITOGEN-ACTIVATEDYES1SRCPRKAA1LCKCYCLIN-DEPENDENTKDRPROTEINFYNRIPK2KITMETBLKCSF1RPLK4MAP3K3ROCK2FOCALBCRSLKPROTO-ONCOGENELYNRETAURKADYRK2AXLMAP4K5MINK1ROCK1INSRMAP3K7EPHB6FRKHIPK4IRAK1STK10IKBKBRPS6KB1STK3JAK3TYK2TEKABL2FGFR3FGRFLT1NTRK1HIGHIGF1RTXKHPNAAK1AURKCDDR1MAP3K19TNK2EPHA3EPHB4LIMK1NTRK2PTK2BTAOK1ALKEPHA6ROS1TBK1BMP2KCAMKK2CDKL2EIF2AK2MAP4K3MERTKRECEPTOR-INTERACTINGSRPK1STK4TESK1TIE1TNK1ULK3BTKEPHA2EPHA4EPHA8EPHB1EPHRINFESLIMK2NTRK3PRKD2PRKD3TNNI3KHEPATOCYTESBK1MST1RIKBKEANKK1BMPR1BDLK1GRK4ITKMAP3K12NUAK2RIOK1RIOK3RIPK4SRPK3ULK2ACVR1ACVR1BCDK11BDMPKEPHA1EPHA5EPHA7FERFPGT-TNNI3KHLAIRAK3MAP3K1MUSKNT-3PRKD1STK26TAOK2TAOK3TGFBR1TYRO3ZAP70ACAD11BMXCASKCD74CDK11ACOQ8BDCLK1DCLK2DSTYKECHINODERMEML4H-2INPPL1INSRRINTERLEUKIN-1LEUKOCYTELTKMAP2K3MAP3K13MAP3K15MAP3K2MAPK6MAPK7MIXEDNEK7NEK9NIM1KNPM1NUCLEOPHOSMINPIP5K1ASBK3SLC34A2STK35SYNDECAN-4TGF-BETAULK1VON
205 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases28 targets overlapping
Signaling by Interleukins20 targets overlapping
EPH-Ephrin signaling18 targets overlapping
Uncovered Pathway Targets
276 totalADAM10ADAM17AKT3APH1AAPH1BATP6V1B2BRAFCDC37CDC42CDK5+266 more…
Genes present in the top pathway union that Crizotinib does not directly modulate.
Top Stack Candidates
Bortezomib
score 14,013.084#1 gap-filler · 50 targets covered · evidence score 44.2
CMA1CREB1ESR1HDAC1HDAC2HDAC3HIF1AHSPB1PGRPLATADRM1CA1+38
Dasatinib
score 7,323.771#2 gap-filler · 29 targets covered · evidence score 45.0
BRAFCREB1CSKEGFRERBB2ERBB4ESR1FGFR1FGFR2GABRA1JAK2MAP2K1+17
770 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.