BiohacksAI/Mechanism Hypothesis/cycloheximide

cycloheximide — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARESR1TDP1THRBESRRASYKTYROSINE-PROTEINGLI3PGRNSD2RORCMUSHISTONE-LYSINENUCLEARTP53NR3C1ABCB1RARAHOMODRD2CYP19A1AHRIFNGPPARGVDRATXN2ATAD5CFTRSMAD3STK33MDM2IL1BMDM4SMAD2IFNB1IDH1HIF1AMITFCREB1YAP1TOP1P1PPARDHLA-BBRCA1HSP90AA1PPP1R15ABARD1NR5A1NR5A2NLRP3NCOA3HSF1GLP1REPAS1NCOA1NR2F2PLGTFE3NCOA2GLI1PRNPPLAURIPK2PLAURSLC2A1FOCALNOD2FKBP1APTK2BALKEIF4A1EEF2

72 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation14 targets overlapping

SUMO E3 ligases SUMOylate target proteins14 targets overlapping

Deubiquitination14 targets overlapping

Uncovered Pathway Targets

224 total

AURKAAURKBBIRC5BLMCREBBPCTBP1DNMT1DNMT3BEIF2AK2EP300+214 more…

Genes present in the top pathway union that cycloheximide does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 42 targets covered · evidence score 44.2

score 12,431.361

HDAC1HDAC2NFKB2NR1I2PARP1RELAADRM1PSMA1PSMA2PSMA3PSMA4PSMA5+30

Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 34 targets covered · evidence score 40.6

score 7,389.029

AURKBBLMNFKB2NR1H2NR1H3PARP1RELATOP1WRNCDK1OTUD3POLB+22

698 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.