Dasatinib — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARNR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7SYKTYROSINE-PROTEINPGRNSD2RORCMUSHISTONE-LYSINENUCLEARTP53NR3C1RARAESR2CYP19A1AHRIFNGPPARGTSHRNTMT1ATXN2SMAD3GMNNSMAD2CREB1CASP3NNMTPNMTTOP1P1GAMTGNMTHNMTPPARDCATECHOLCASP7NR0B1ABL1AURKBEPIDERMALJAK2GABRA1RAC-ALPHAMITOGEN-ACTIVATEDNR2F2MAPK14YES1SRCLCKKDRPRNPFYNRIPK2KITBLKCSF1RPLK4DYRK3MACROPHAGESLKDUALPROTO-ONCOGENELYNRETMAP2K1CSNK1EAXLGAKMAPK11MAP3K20MAP4K5MINK1BRAFEGFRFRKSTK10FGFR1PDGFRBPLATELET-DERIVEDABL2FGFR3FGRMAP2K2ERBB4HCKTXKCDC42BPAPKN2DDR1DDR2TNIKTNK2EPHA3EPHB4LIMK1TAOK1TGFBR2ERBB2CSKFGFR2MAP4K3TESK1BTKEPHA2EPHA4EPHA8EPHB1EPHRINFESLIMK2TNNI3KPDGFRARAF1ACVR2BCDC42BPBMAP3K4ACVR1ACVR1BDMPKSTK26TGFBR1EPHB2IRAK4NLKPTK6SRMSSTK36ACVR2AACVRL1BREAKPOINTCDC42BPGCOQ8ACYTOPLASMICDISCOIDINEIF2AK4EPHB3EPITHELIALMAP3K10MYELINPKMYT1RAC-BETARAC-GAMMASIK1SIK2SIK3TEC
152 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Receptor Tyrosine Kinases30 targets overlapping
Intracellular signaling by second messengers19 targets overlapping
PIP3 activates AKT signaling19 targets overlapping
Uncovered Pathway Targets
245 totalADAM10ADAM17AKT3ALKAPH1AAPH1BATP6V1B2CDC37CDC42CDK5+235 more…
Genes present in the top pathway union that Dasatinib does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,110.69#1 gap-filler · 39 targets covered · evidence score 44.2
CMA1HDAC1HDAC2HDAC3HIF1AHSPB1PLATADRM1PSMA1PSMA2PSMA3PSMA4+27
sp600125
score 7,810.481#2 gap-filler · 30 targets covered · evidence score 43.3
CDK5CHEK1FERFLT1FLT3FLT4HIF1AINSRJAK3MAPK1MAPK12MATK+18
438 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.