BiohacksAI/Mechanism Hypothesis/Demecolcine

Demecolcine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARNR1I2ESR1TDP1THRBSYKTYROSINE-PROTEINNSD2HISTONE-LYSINETP53ABCB1ATAD5MDM2MDM4MITFBRCA1BARD1PAX8NR0B1PARP1POLYTFE3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8

37 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle21 targets overlapping

Hemostasis16 targets overlapping

Cell Cycle, Mitotic16 targets overlapping

Uncovered Pathway Targets

222 total

ABL1ADRM1AKT3ATMAURKAAURKBBIRC5BLMCCNA1CCNB1+212 more…

Genes present in the top pathway union that Demecolcine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 38 targets covered · evidence score 44.2

score 11,894.404

ADRM1HDAC1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+26

Sorafenib

#2 gap-filler · 28 targets covered · evidence score 44.4

score 7,001.894

ABL1AURKAAURKBCDK1CDK6CDK7CSNK1A1GMNNGSK3BLYNMAPK1MAPK11+16

486 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.