BiohacksAI/Mechanism Hypothesis/Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.

Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARNR1I2ESRRANFE2L2NUCLEARABCB1IFNGTSHRCFTRSMAD3STK33MDM2IL1BMDM4OPRM1IDH1HIF1AMITFYAP1OPRD1BRCA1PPP1R15AGPR151BARD1NR5A1HTR5APAX8NR5A2NCOA3ITGA4TNFRSF10BEPAS1MELANOCORTINNR2F2SLCO4C1GPR119ATP1A1ATP1B1ATP1A2

39 known targets mapped from PubChem bioassay data

Pathway Context

Deubiquitination8 targets overlapping

SUMOylation7 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Uncovered Pathway Targets

268 total

ADRB2ADRM1ARRB1BAP1CCNA1CDC25ACDK1EP300ESR1IDE+258 more…

Genes present in the top pathway union that Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 50 targets covered · evidence score 44.2

score 13,672.681

ADRM1ESR1NLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+38

Quercetin

#2 gap-filler · 45 targets covered · evidence score 43.4

score 9,402.074

CDK1ESR1OTUD3POLBPSMB5SMAD2TP53UCHL1USP10USP17L5USP28USP30+33

815 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.