Dihydroergocornine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
DRD35-HYDROXYTRYPTAMINEADRA1ADRD2DRD1HTR1AADRA2AHTR2BADRA2CADRA2BHTR2CHRH2
12 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)11 targets overlapping
Amine ligand-binding receptors11 targets overlapping
G alpha (i) signalling events4 targets overlapping
Uncovered Pathway Targets
312 totalADORA2BADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AGTR2APLNR+302 more…
Genes present in the top pathway union that Dihydroergocornine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,745.175#1 gap-filler · 33 targets covered · evidence score 44.3
ADRA1BADRA1DADRB1ADRB2ADRB3DRD4TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13+21
Astemizole Antihistamine drug now withdrawn from
score 5,543.964#2 gap-filler · 25 targets covered · evidence score 48.7
ADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD4GALR2GHSRHRH1HRH4HTR2A+13
825 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.