Disulfiram — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2ESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3PGRNSD2RORCMUSHISTONE-LYSINENUCLEARTP53ABCB1KCNH2RARAEUCHROMATICCHRM1DRD35-HYDROXYTRYPTAMINEHTR2ACYP19A1AHRPPARGADRB2VDRJUNNTMT1ATXN2ATAD5ACHEPMP22CFTRMU-TYPESMAD3KAPPA-TYPEALDEHYDEGMNNSODIUM-DEPENDENTSTK33IL1BSMAD2ALPHA-2AIFNB1ABCB11CREB1ADORA3CASP3NNMTPNMTALPHA-2BTOP1P1GAMTGNMTHNMTPPARDCATECHOLHSPB1HLA-BCASP7KCNMB1GFERNFKB1GLSHSP90AA1RGS4PPP1R15ACBX1ALOX12PTGER2APPGPR32MTORHPGDTHPOMPHOSPH8TRPA1ADENOSINENLRP3IP6K1TAAR1PDE4AGPT2PRMT1KCNJ2CGASADCY9PIP4K2AMITOGEN-ACTIVATEDAGTR1NPR2PLK1PSMB5LRRC26NOD1CASP1CIB1EHMT2CBFBRUNX1PLIN5SMARCA2TOR1AFXNEHMT1APLNRINOSITOLNPR1NLRP1LYSINE-SPECIFICCCR6ALDH2FBP1CXCR6PLIN1MONOGLYCERIDECBR3LOXSARM1ALDH1A1PHOSPHO1C-CC-X-CGSDMDLOXL2LOXL3LOXL4PHGDH
139 known targets mapped from PubChem bioassay data
Pathway Context
Signaling by Interleukins13 targets overlapping
Signaling by Nuclear Receptors13 targets overlapping
Biological oxidations12 targets overlapping
Uncovered Pathway Targets
398 totalADRM1ALOX15ALOX5ANXA2BCL2L1BIRC5CA1CCL2CDC42CFL1+388 more…
Genes present in the top pathway union that Disulfiram does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,246.445#1 gap-filler · 41 targets covered · evidence score 44.2
ADRM1CA1CTSGHIF1AIFNGNFKB2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6+29
Crizotinib
score 8,412.827#2 gap-filler · 31 targets covered · evidence score 46.7
CSF1RFYNIFNGIKBKBINPPL1IRAK1IRAK3JAK3LCKLYNMAP2K3MAP3K3+19
887 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.