Domperidone — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2D6NR1I2ESR1TDP1THRBESRRACYP3A7SYKTYROSINE-PROTEINGLI3RATTUSNSD2HISTONE-LYSINEKCNH2CHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1HTR1AADRB2HTR2BTSHRADRA2CJUNADRA2BATAD5SLC6A3PMP22MU-TYPESMAD3KAPPA-TYPESODIUM-DEPENDENTHRH1RXRASMAD2ALPHA-2AALPHA-2BALPHA-1DALPHA-1AALPHA-2CALPHA-1BHISTAMINEPDE4DMCL1SCN5AAPAF1SLC22A2SLC47A1ABHD17BBCL2L1ALPLAOX1
55 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)13 targets overlapping
Amine ligand-binding receptors12 targets overlapping
Signaling by Interleukins5 targets overlapping
Uncovered Pathway Targets
318 totalADORA2BADORA3ADRA1BADRA1DADRA2AADRB1ADRB3AGTR1AGTR2APLNR+308 more…
Genes present in the top pathway union that Domperidone does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,768.418#1 gap-filler · 46 targets covered · evidence score 44.2
ADRM1CA1CREB1CTSGHIF1AIFNGNFKB1NFKB2PSMA1PSMA2PSMA3PSMA4+34
Sorafenib
score 6,441.7#2 gap-filler · 27 targets covered · evidence score 44.4
ADORA3HTR2CHTR6HTR7MLNRCSF1RFYNHCKIFNGIRAK1JAK3LCK+15
929 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.