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BiohacksAI

Evidence-Based Biohacking

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BiohacksAI/Mechanism Hypothesis/Emetine

Emetine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

ARNR1I2ESR1TDP1THRBESRRASYKTYROSINE-PROTEINCHAINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53NR3C1ABCB1KCNH2RARAADRA1AESR2CYP19A1ADRA2AVDRADRA2CATXN2ATAD5NR1H4MU-TYPESMAD3STK33SMAD2ALPHA-2AIFNB1HIF1ACREB1YAP1TOP1P1HLA-BALPHA-1AALPHA-2CALPHA-1BMTOREPAS1GPR35TRPM7SLC2A1RBBP9

49 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway10 targets overlapping
SUMOylation9 targets overlapping
SUMO E3 ligases SUMOylate target proteins9 targets overlapping

Uncovered Pathway Targets

137 total
ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1NR1D1NR1D2NR1H2+127 more…

Genes present in the top pathway union that Emetine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 40 targets covered · evidence score 44.2

score 12,061.124
PPARDHDAC1HDAC2MITFNFKB2PARP1RELAADRM1NLRP3PSMA1PSMA2PSMA3+28
Luteolin 5,7,3',4'-tetrahydroxy-flavone,

#2 gap-filler · 24 targets covered · evidence score 40.6

score 5,312.484
NR1H2NR1H3PPARGAURKBBLMNFKB2PARP1RELATOP1WRNCDK1CFTR+12

428 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.