BiohacksAI/Mechanism Hypothesis/Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as
Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4NFE2L2CHAINGLI3PGRRORCMUSNUCLEARTP53NR3C1RARAEUCHROMATICESR2CYP19A1AHRPPARGNTMT1ACHENR1H4MAPTALDEHYDECASP3HDAC9NNMTPNMTGAMTGNMTHNMTCATECHOLHDAC6MAOAPOLBCBX1THPOMPHOSPH8FEN1ESTROGENSENP8PLA2G7CYP1B1MAOBKCNQ1ANO1CLK1CSNK2A1ADCY9AKR1B1PIP4K2APHOSPHATIDYLINOSITOLPIM1DYRK1ACSNK2A2PSMB5CSNK2BPIM2SENP6CXCL8CSNK2A3SENP7NPR1PSMB1FTONPC1L1PTP4A3
75 known targets mapped from PubChem bioassay data
Pathway Context
Biological oxidations12 targets overlapping
Phase I - Functionalization of compounds11 targets overlapping
Intracellular signaling by second messengers11 targets overlapping
Uncovered Pathway Targets
185 totalAADACAHCYALDH1A1ALDH2AOC1ARNTCBR3CES1CES2CYP11B1+175 more…
Genes present in the top pathway union that Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as does not directly modulate.
Top Stack Candidates
Bortezomib
score 10,902.618#1 gap-filler · 35 targets covered · evidence score 44.2
ADRM1CREB1HDAC1HDAC2HDAC3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7+23
Sorafenib
score 5,465.625#2 gap-filler · 21 targets covered · evidence score 44.4
CAMK2BEZH2FGFR1FGFR2FGFR3FLT3FRKFYNGSK3BINSRIRAK1KIT+9
508 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.