Estramustine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARESR1CHAINTP53ESR2VDRNTMT1NR1H4POLKUSP1KAT2ABLM
12 known targets mapped from PubChem bioassay data
Pathway Context
SUMOylation6 targets overlapping
SUMO E3 ligases SUMOylate target proteins6 targets overlapping
Nuclear Receptor transcription pathway5 targets overlapping
Uncovered Pathway Targets
143 totalAURKAAURKBBIRC5BRCA1CREBBPCTBP1DNMT1DNMT3BEIF2AK2EP300+133 more…
Genes present in the top pathway union that Estramustine does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,998.658#1 gap-filler · 47 targets covered · evidence score 44.2
HDAC1HDAC2MITFNFKB2NR1I2PARP1PGRRARARELAESRRAPPARDADRM1+35
Luteolin 5,7,3',4'-tetrahydroxy-flavone,
score 5,117.775#2 gap-filler · 23 targets covered · evidence score 40.6
AURKBNFKB2NR1H2NR1H3PARP1PPARGRELATOP1WRNCDK1CFTROTUD3+11
625 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.