Everolimus — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARESR1TDP1THRBMUSNR3C1HOMOCYP19A1ABCB11MTORFKBP1AMLST8RPTORFKBP4FKBP5
15 known targets mapped from PubChem bioassay data
Pathway Context
Intracellular signaling by second messengers4 targets overlapping
PIP3 activates AKT signaling4 targets overlapping
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand4 targets overlapping
Uncovered Pathway Targets
152 totalADCY9ADRM1AGO2AKT3BADCAMK2BCAMK2DCAMKK1CAMKK2CASP9+142 more…
Genes present in the top pathway union that Everolimus does not directly modulate.
Top Stack Candidates
Bortezomib
score 11,609.481#1 gap-filler · 39 targets covered · evidence score 44.2
ADRM1CREB1ESR2HDAC1HDAC2HDAC3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6+27
sp600125
score 5,894.344#2 gap-filler · 24 targets covered · evidence score 43.3
CAMK2BCAMK2DCAMKK2CSNK2A1ERBB4FGFR1FGFR3FLT3FRKGSK3AGSK3BINSR+12
467 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.