BiohacksAI/Mechanism Hypothesis/fisetin

fisetin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C9CYP1A2CYP3A4SYKNTMT1ACHEMAPTPOLKHDAC6ALOX12ALOX15MAPK1GSK3BAURKBCDK1SLCO2B1CLK1CSNK2A1GSK3ATOP2APIM1CDK5CSNK2A2XDHMAPK14MAPK10PKMCSNK2BPIM2STK16TOP1CDK5R1CSNK2A3CCNB1CCNB2CCNB3FHRPS6KA3CDK6IMPA1MAP3K5RPS6KA1PDK1ARG1RPS6KA2

45 known targets mapped from PubChem bioassay data

Pathway Context

Cell Cycle12 targets overlapping

Cell Cycle, Mitotic11 targets overlapping

Signaling by Interleukins9 targets overlapping

Uncovered Pathway Targets

278 total

ABL1ADRM1AKT3ATMAURKABARD1BIRC5BLMBRCA1CCNA1+268 more…

Genes present in the top pathway union that fisetin does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 47 targets covered · evidence score 44.2

score 13,274.86

ADRM1HDAC1HDAC8NSD2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+35

Crizotinib

#2 gap-filler · 35 targets covered · evidence score 46.7

score 9,960.568

ABL1AURKACDK11ACDK11BEML4LYNNEK7NEK9NPM1NSD2PLK4SRC+23

629 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.