gedunin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
GMNNMDM2MDM4HIF1ABRCA1HSP90AA1BARD1PAX8NPSR1HSP90AB1EPAS1MRGPRX1NCOA2HNF4APLIN5FASNNPBWR1IDEPTGES3
19 known targets mapped from PubChem bioassay data
Pathway Context
Cell Cycle7 targets overlapping
Deubiquitination6 targets overlapping
Signaling by Nuclear Receptors4 targets overlapping
Uncovered Pathway Targets
229 totalABL1ADRM1AKT3ATMAURKAAURKBBIRC5BLMCCNA1CCNB1+219 more…
Genes present in the top pathway union that gedunin does not directly modulate.
Top Stack Candidates
Bortezomib
score 12,938.167#1 gap-filler · 48 targets covered · evidence score 44.2
ADRM1HDAC1HDAC8NSD2PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+36
Quercetin
score 8,715.977#2 gap-filler · 40 targets covered · evidence score 43.4
ABL1AURKBBLMCDK1CSNK2A1CSNK2A2CSNK2BFEN1GSK3BMAPK14NEK2NEK6+28
716 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.