BiohacksAI/Mechanism Hypothesis/Gemfibrozil

Gemfibrozil — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2C9CYP1A2ESRRASYKTYROSINE-PROTEINRATTUSRORCRARAAHRHTR2BJUNRXRAHDAC9ABCC2NR5A1SLCO1B1NR5A2SLCO1B3PPARATTRFABP1CISD1CYP2C8RORARARBPI4K2ANR1H2RARGNR2F1

30 known targets mapped from PubChem bioassay data

Pathway Context

Nuclear Receptor transcription pathway11 targets overlapping

SUMOylation7 targets overlapping

SUMO E3 ligases SUMOylate target proteins7 targets overlapping

Uncovered Pathway Targets

119 total

ARESR1ESR2ESRRBESRRGHNF4AHNF4GNCOR1NCOR2NR0B1+109 more…

Genes present in the top pathway union that Gemfibrozil does not directly modulate.

Top Stack Candidates

Quercetin

#1 gap-filler · 22 targets covered · evidence score 43.4

score 4,174.301

ARESR1NR1I2NR3C1PGRPPARGAURKBBLMNFKB2RELATOP1TOP2A+10

Daunorubicin

#2 gap-filler · 24 targets covered · evidence score 41.9

score 4,145.783

ARESR1ESR2NR1H4NR1I2NR3C1PGRPPARDPPARGVDRBLMHDAC1+12

675 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.