BiohacksAI/Mechanism Hypothesis/Glyburide

Glyburide — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6CYP2C9NR1I2CYTOCHROMECYP3A4CYP3A7RATTUSMUSABCB1HOMOPPARGCFTRABCB11KCNMB1ABCC2SLCO1B1SLC22A6KCNMB4NLRP3SLCO2B1CISD1KCNJ8KCNJ5KCNJ11SLC15A2ABCC8ABCC9SURF1

29 known targets mapped from PubChem bioassay data

Pathway Context

Drug ADME8 targets overlapping

Aspirin ADME6 targets overlapping

Disorders of transmembrane transporters6 targets overlapping

Uncovered Pathway Targets

137 total

ABCC1ABCC3ABCC4ABCC5ABCG2ADAADKAKR1C1ALBBCHE+127 more…

Genes present in the top pathway union that Glyburide does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 34 targets covered · evidence score 44.2

score 10,599.919

ADRM1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4+22

Reserpine

#2 gap-filler · 18 targets covered · evidence score 41.7

score 4,615.103

BCHEPSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4+6

623 more candidates · full stack optimisation locked

Enter your API token to unlock the complete analysis.

BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.