BiohacksAI/Mechanism Hypothesis/Guanabenz

Guanabenz — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2D6ARTDP1CYP1A2THRBCYP3A75-HYDROXYTRYPTAMINEADRA1AHTR2ADRD1HTR1AIFNGADRA2AADRA2CADRA2BMU-TYPESLC6A2ALPHA-2AADRA1BADRA1DNNMTPNMTALPHA-2BGAMTGNMTHNMTALPHA-1DCATECHOLALPHA-1AALPHA-2CMAOAALPHA-1BTAAR1SLC22A1AMINENISCHMAP3K3

37 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)10 targets overlapping

Amine ligand-binding receptors10 targets overlapping

Adrenoceptors6 targets overlapping

Uncovered Pathway Targets

251 total

ADORA2BADORA3ADRB1ADRB2ADRB3AGTR1AGTR2APLNRAPPAVPR1A+241 more…

Genes present in the top pathway union that Guanabenz does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 36 targets covered · evidence score 44.2

score 10,806.708

CYP19A1CYP2C19CYP3A4ADRM1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1+24

Astemizole Antihistamine drug now withdrawn from

#2 gap-filler · 29 targets covered · evidence score 48.7

score 5,873.195

ADRB2APLNRAVPR1ACHRM1CHRM2CHRM3DRD2DRD3DRD4GALR2GHSRHRH1+17

924 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.