BiohacksAI/Mechanism Hypothesis/Hexachlorophene

Hexachlorophene — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3PGRNSD2RORCHISTONE-LYSINENUCLEARTP53ABCB1RARACHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2AESR2DRD1CYP19A1HTR1AIFNGPPARGADRB2VDRTSHRPTGS1NTMT1ATXN2SLC6A3ACHEPMP22CFTRMU-TYPESLC6A2SMAD3MAPTGMNNSODIUM-DEPENDENTSTK33MDM2MDM4ANDROGENALPHA-2AIDH1ADORA3PPARDHSPB1HTTBRCA1ALPHA-2CBAZ2BPOLBNFKB1HSP90AA1RAPGEF4BARD1ALOX12PTGER2ALOX15PAX8HPGDRAPGEF3USP1GPX4MCL1PHOSPHOLIPIDADENOSINEPOLHCGMP-INHIBITEDNPY1RNLRP3KAT2APLA2G7TRHRKCNQ1RXFP1PDE4AEPIDERMALANO1THYROIDNPY2RTRPC6MRGPRX1CGASALOX15BHCRTR1TRPC4CACNA1HMELANOCORTINPROSTAGLANDINMITOGEN-ACTIVATEDPPP1CAPLK1KCNQ2SLC5A7DDIT3PABPC1NOD1HSPD1HSPE1EIF4HABHD17BSIRT5PRNPSAE1UBA2CASP1CASP6SUBSTANCE-KKLF5EIF4EATG4BHEATTHROMBOXANE-AEIF4G1PRKNSUMO-CONJUGATINGACETYLCHOLINESTERASESTAT1FASNVCPPLA2G1BNLRP1GALK1PINK1RECEPTORMIFUSP2SLC12A5SCARB1ITGALPAFAH2ADAM10SUMO1CYP51PPME1HSPA5HSPA8PPM1DSERPINE1SMALLENDOPLASMICGZMBNAPEPLD

158 known targets mapped from PubChem bioassay data

Pathway Context

Deubiquitination16 targets overlapping

Class A/1 (Rhodopsin-like receptors)15 targets overlapping

SUMOylation13 targets overlapping

Uncovered Pathway Targets

323 total

ADRM1ARRB1BAP1CCNA1CDC25ACDK1EP300HIF1AIDEKAT2B+313 more…

Genes present in the top pathway union that Hexachlorophene does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 43 targets covered · evidence score 44.2

score 12,702.812

ADRM1HIF1APSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3+31

Quercetin

#2 gap-filler · 37 targets covered · evidence score 43.4

score 8,100.467

CDK1HIF1AOTUD3PSMB5SMAD2UCHL1USP10USP17L5USP28USP30USP7USP8+25

838 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.