Hydroxyzine — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6CYP2C9CYTOCHROMETHRBESRRACYP3A7MUSKCNH2CHRM1DRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2IFNGADRB2HTR2BADRA2CADRA2BKAPPA-TYPECHRM2HRH1ADRA1BADRA1DHRH2HTR7HTR6DRD4SCN2AHTR5ASCN3ASCN1AIP6K1INOSITOLEBP
36 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)17 targets overlapping
Amine ligand-binding receptors17 targets overlapping
G alpha (q) signalling events7 targets overlapping
Uncovered Pathway Targets
210 totalADORA2BADORA3ADRA2AADRB1ADRB3AGTR1AGTR2APLNRAPPAVPR1A+200 more…
Genes present in the top pathway union that Hydroxyzine does not directly modulate.
Top Stack Candidates
Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on
score 9,052.97#1 gap-filler · 29 targets covered · evidence score 44.3
ADRB1ADRB3TSHRCREB1GRK2TAS2R1TAS2R10TAS2R13TAS2R14TAS2R16TAS2R19TAS2R20+17
Fluspirilene
score 4,243.262#2 gap-filler · 17 targets covered · evidence score 49.7
ADORA3CHRM3GHSRHCRTR1HTR1AHTR1EMC3RMLNRNPSR1NTSR1OPRD1OPRL1+5
650 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.