BiohacksAI/Mechanism Hypothesis/Idarubicin

Idarubicin — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

THRBSYKTYROSINE-PROTEINCHAINPGRNSD2HISTONE-LYSINETP53NR3C1KCNH2EUCHROMATICDRD1IFNGADRA2CATAD5PMP22SLC6A4SLC6A2HTR2CMAPTHRH1IFNB1POLKHLA-BHTTPOLBHSP90AA1RAPGEF4CBX1MTORPOLIRAPGEF3USP1MPHOSPH8FEN1POLHBLMGNAI1RGS12HSP90AB1CGASTOP2AGHSRAICDACD47SIRPACCDC88AGNAI3YWHAGSON

50 known targets mapped from PubChem bioassay data

Pathway Context

Hemostasis9 targets overlapping

DNA Repair9 targets overlapping

Cell Cycle8 targets overlapping

Uncovered Pathway Targets

311 total

ABCC4ABL1ADRA2AADRA2BALBANXA2APPARRB1ATP1B1ATP1B2+301 more…

Genes present in the top pathway union that Idarubicin does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 43 targets covered · evidence score 44.2

score 12,815.402

F12HDAC1HDAC2PLATPARP1SEM1ADRM1HDAC8PSMA1PSMA2PSMA3PSMA4+31

Crizotinib

#2 gap-filler · 31 targets covered · evidence score 46.7

score 9,148.52

ABL1CD74FGRFYNLCKLYNMERTKSRCTEKYES1AURKAAURKB+19

634 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.