indirubin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
NSD2HISTONE-LYSINEAHRGSK3BCDK1GSK3ACDK5CYCLIN-DEPENDENTCDK5R1CCNB1CCNB2CCNB3CYCLIN-A2CDK6WEE1CDK16NCF1CDK11BCDK14CDK15CDK17CDK18CDK3CDK10CDK20CDK4
26 known targets mapped from PubChem bioassay data
Pathway Context
Cell Cycle9 targets overlapping
Cell Cycle, Mitotic8 targets overlapping
Cell Cycle Checkpoints6 targets overlapping
Uncovered Pathway Targets
135 totalABL1ADRM1AKT3ATMAURKAAURKBBARD1BIRC5BLMBRCA1+125 more…
Genes present in the top pathway union that indirubin does not directly modulate.
Top Stack Candidates
Bortezomib
score 10,953.086#1 gap-filler · 35 targets covered · evidence score 44.2
ADRM1HDAC1HDAC8PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2+23
Nocodazole Nocodazole is
score 5,341.988#2 gap-filler · 24 targets covered · evidence score 42.9
ABL1BARD1BRCA1GMNNMDM2MDM4TP53TUBA1ATUBA1BTUBA1CTUBA3CTUBA3E+12
302 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.