Indomethacin — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
ARCYP1A2RATTUSMUSABCB1HOMOPPARGPTGS1SLC6A3PTGS2SLC22A8HPGDSLC22A6ABCC1AKR1B1ALOX5PROSTAGLANDINCXCL8AKR1C3PTGESALDO-KETOPTGDR2SLC22A7PTGDSTBXAS1
25 known targets mapped from PubChem bioassay data
Pathway Context
Fatty acid metabolism8 targets overlapping
Arachidonate metabolism8 targets overlapping
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)5 targets overlapping
Uncovered Pathway Targets
69 totalACAD11ALOX12ALOX15ALOX15BCBR1CPT2CYP1A1CYP1B1CYP2C19CYP2C8+59 more…
Genes present in the top pathway union that Indomethacin does not directly modulate.
Top Stack Candidates
Quercetin
score 2,919.936#1 gap-filler · 15 targets covered · evidence score 43.4
ALOX12ALOX15ALOX15BCYP1A1CYP1B1CYP2C19CYP2C8CYP2C9PON1PRKAA2RXRAABCG2+3
scutellarein
score 1,865.503#2 gap-filler · 7 targets covered · evidence score 43.4
CYP1A1CYP1B1SLCO2B1UGT1A1UGT1A10UGT1A3UGT1A9
690 more candidates · full stack optimisation locked
Enter your API token to unlock the complete analysis.
BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.