BiohacksAI/Mechanism Hypothesis/Irinotecan

Irinotecan — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

TDP1SYKTYROSINE-PROTEINNSD2MUSHISTONE-LYSINEIFNGATXN2ACHEALPHA-2CMUSCARINICGPX1GLUTATHIONESLC22A2PARP1SLC47A1POLYTOP1ACETYLCHOLINESTERASESLC47A2INTERSTITIALSERINE-PROTEIN

22 known targets mapped from PubChem bioassay data

Pathway Context

SUMOylation2 targets overlapping

SUMO E3 ligases SUMOylate target proteins2 targets overlapping

Signaling by Interleukins2 targets overlapping

Uncovered Pathway Targets

234 total

ARAURKAAURKBBIRC5BLMBRCA1CREBBPCTBP1DNMT1DNMT3B+224 more…

Genes present in the top pathway union that Irinotecan does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 49 targets covered · evidence score 44.2

score 13,304.665

ARESR1HDAC1HDAC2MITFNFKB2NR1I2PGRRARARELATP53ADRM1+37

Quercetin

#2 gap-filler · 39 targets covered · evidence score 43.4

score 7,379.37

ARAURKBBLMESR1NFKB2NR1I2NR3C1PGRPPARGRELARXRATOP2A+27

800 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.