ketoconazole — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C9TDP1CYP1A2CYP3A4SNCAUGT1A1HMOX1HMOX2
8 known targets mapped from PubChem bioassay data
Pathway Context
Biological oxidations4 targets overlapping
Drug ADME3 targets overlapping
Phase I - Functionalization of compounds3 targets overlapping
Uncovered Pathway Targets
84 totalAADACAHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CES2+74 more…
Genes present in the top pathway union that ketoconazole does not directly modulate.
Top Stack Candidates
Quercetin
score 3,085.75#1 gap-filler · 16 targets covered · evidence score 43.4
AHRCYP19A1CYP1A1CYP1B1CYP2C19CYP2C8HSP90AB1MAOANNMTRXRAABCB1ABCC1+4
Ritonavir
score 2,666.42#2 gap-filler · 11 targets covered · evidence score 53.4
CYP2B6CYP2C19CYP2D6CYP3A43CYP3A5CYP3A7CYP3A7-CYP3A51PABCB1SLCO1B1SLCO1B3SLCO2B1
754 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.