BiohacksAI/Mechanism Hypothesis/lidoflazine

lidoflazine — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9TDP1ESRRACYP3A7SYKTYROSINE-PROTEINNSD2RORCHISTONE-LYSINEABCB1KCNH2RARADRD35-HYDROXYTRYPTAMINEADRA1AHTR2ADRD2DRD1ADRA2AHTR2BADRA2CADRA2BATXN2SLC6A3SLC6A4SLC6A2KAPPA-TYPEHRH1MDM2IL1BMDM4BRCA1BARD1SCN2ASCN3ASCN1AAPAF1SLC29A1

41 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)10 targets overlapping

Amine ligand-binding receptors10 targets overlapping

Drug ADME5 targets overlapping

Uncovered Pathway Targets

352 total

ADORA2BADORA3ADRA1BADRA1DADRB1ADRB2ADRB3AGTR1AGTR2APLNR+342 more…

Genes present in the top pathway union that lidoflazine does not directly modulate.

Top Stack Candidates

Bortezomib

#1 gap-filler · 41 targets covered · evidence score 44.2

score 11,864.057

CYP3A4ADRM1ESR1HIF1ANLRP3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7+29

Quercetin

#2 gap-filler · 48 targets covered · evidence score 43.4

score 10,685.31

ADORA3APPAVPR2CCR4CHRM2CXCR1DRD4GPR35ABCC1ABCG2CYP2C8CYP3A4+36

942 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.